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Update Functional annotations authored by Baptiste Imbert's avatar Baptiste Imbert
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Layers/Functional-annotations.md
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......@@ -11,6 +11,7 @@ title: Functional annotations
Functional annotation helps bringing biological meaning to genetic sequences. Functional annotation is usually obtained through protein sequence similarity. Indeed, across two organisms, if two sequences are very similar, one can infer that they can encode for the same biological function.
There are several main parameters that will impact the process of functional annotation:
- how distant is the species which was actually annotated with experimental data (the reference)
......@@ -24,7 +25,7 @@ In Ortho_KB, we integrate functional annotation from EggNOG, MapMan, InterPro an
## EggNOG
The annotation tool EggNOG-mapper (https://github.com/eggnogdb/eggnog-mapper) relies on EggNOG databases to annotate genes with knowledge from orthologs on other genomes.
The annotation tool EggNOG-mapper (https://github.com/eggnogdb/eggnog-mapper) relies on EggNOG databases to annotate genes with knowledge from orthologs on other genomes. It uses a **FASTA of proteins**.
### Install
First, install emapper, which can be done for example with conda:
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