... | ... | @@ -10,6 +10,7 @@ title: Functional annotations |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Functional annotation helps bringing biological meaning to genetic sequences. Functional annotation is usually obtained through protein sequence similarity. Indeed, across two organisms, if two sequences are very similar, one can infer that they can encode for the same biological function.
|
|
|
There are several main parameters that will impact the process of functional annotation:
|
|
|
- how distant is the species which was actually annotated with experimental data (the reference)
|
... | ... | @@ -126,6 +127,7 @@ Few genes are annotated by this category. |
|
|
`is_hidden` informs on whether the term is the most informative. If another more informative term annotates the gene, the term is hidden (1). This allows to reduce the number of effective annotations per gene and take advantage of the structure of the ontology instead.
|
|
|
|
|
|
_Note 1: the download of files does not seem on Chrome (tested on Firefox)_
|
|
|
|
|
|
_Note 2: TRAPID is no longer actively updated. Other options will be considered_
|
|
|
|
|
|
## InterPro
|
... | ... | |