| ... | ... | @@ -8,6 +8,7 @@ title: Functional annotations |
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Functional annotation helps bringing biological meaning to genetic sequences. Functional annotation is usually obtained through protein sequence similarity. Indeed, across two organisms, if two sequences are very similar, one can infer that they can encode for the same biological function.
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There are several main parameters that will impact the process of functional annotation:
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- how distant is the species which was actually annotated with experimental data (the reference)
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| ... | ... | @@ -56,7 +57,7 @@ The EggNOG-mapper output file includes several categories of annotation, includi |
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## MapMan
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The online annotation tool Mercator4 ([https://www.plabipd.de/mercator_main.html](https://www.plabipd.de/mercator_main.html)) annotate sequences with the MapMan ontology. This ontology is characterized by synthetic descriptors of gene functions. A gene is usually associated to one to two MapMan bins (= terms).
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MapMan requires a protein or DNA input (we use the latter which can provide more annotations).
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MapMan requires a protein or DNA input (we use the latter which can provide more annotations, providing CDS files).
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