D

differential analysis

This project is the source repository of the CRAN package 'hicream' https://cran.r-project.org/package=hicream.

It performs Hi-C data differential analysis based on pixel-level differential analysis and a post hoc inference strategy to quantify signal in clusters of pixels. Clusters of pixels are obtained through a connectivity-constrained two-dimensional hierarchical clustering.

Repository code for the article: Neuvial Pierre, Randriamihamison Nathanaël, Chavent Marie, Foissac Sylvain, and Vialaneix Nathalie (2023) A two-sample tree-based test for hierarchically organized genomic signals. Journal of the Royal Statistical Society, Series C, 73(3), 774–795. https://dx.doi.org/10.1093/jrsssc/qlae011